Explore 20 of the most innovative biotech startups actively hiring in Massachusetts in 2025. Discover cutting-edge job opportunities in therapeutics, gene therapy, AI-driven biotech, and biomedical research.
Massachusetts continues to dominate the U.S. biotech scene with cutting-edge innovation and job creation. From Boston to Cambridge and beyond, a cluster of biotechnology startups are pioneering breakthroughs in AI drug discovery, gene editing, immunotherapy, cell engineering, and diagnostics—and they’re hiring.
Whether you’re a life sciences graduate, experienced researcher, or a tech-savvy biotech engineer, these companies offer roles in biotech project management, clinical trials, lab research, biomedical engineering, bioinformatics, data analytics, and drug development. With Massachusetts being home to top-tier research institutions and venture-backed firms, the region’s biopharma sector promises high-paying jobs with long-term career growth.
Here are 20 of the hottest biotech startups in Massachusetts hiring right now (2025):
1. ODDITY LABS
A research-driven beauty and wellness biotech company, Oddity Labs, formerly known as Revela, specializes in innovation at the intersection of science and consumer products. They are expanding across scientific and operations teams.
Focus: Beauty and wellness biotech
Why Work Here: This startup blends science with cosmetic innovation and is hiring in product R&D, bioinformatics, and clinical testing.
2. Stellaromics Inc.
Stellaromics is pioneering the field of 3D transcriptional mapping in native biological tissues, transforming how researchers understand gene expression at a cellular level.
Focus: 3D gene expression technology
Careers: Now hiring bioinformaticians, lab researchers, and biomedical engineers.
3. Seaport Therapeutics
This clinical-stage biotechnology company is focused on developing neuropsychiatric medications to address unmet medical needs, particularly in disorders involving the central nervous system.
Focus: Neuropsychiatric treatments
Careers: Clinical trial managers, regulatory affairs, and neuroscience research jobs.
4. Pledge Therapeutics
Pledge is transforming early drug development by connecting clinical insights to target identification, with a platform that accelerates the path to preclinical candidates.
Focus: Drug discovery from clinical insights
Careers: Translational medicine, target discovery, and molecule screening.
5. Scismic
Built by scientists, for scientists, Scismic is a technology platform that improves hiring practices and builds diverse, highly qualified teams within biotech organizations.
Focus: Diversity-driven hiring in life sciences
Careers: Product management, software development, talent acquisition specialists.
6. Compass Therapeutics Inc.
A clinical-stage biopharmaceutical company focused on developing therapeutic antibodies for diseases involving angiogenesis and immune modulation.
Focus: Antibody-based therapeutics
Careers: Hiring in immunology research, preclinical and clinical development.
7. Nona Biosciences
Nona offers end-to-end antibody discovery services globally, with solutions that include antigen preparation, immunization, and therapeutic screening.
Focus: Full-cycle antibody discovery
Careers: Protein science, hybridoma development, and immunology.
8. RoslinCT
Leveraging the legacy of Dolly the Sheep, RoslinCT is a contract development and manufacturing organization (CDMO) specializing in cell and gene therapies.
Focus: Cell and gene therapy manufacturing
Careers: Cell therapy technicians, GMP operators, process development engineers.
9. Marengo Therapeutics
Marengo is a clinical-stage immunotherapy company developing treatments that boost specific immune T cell subtypes to combat cancer more effectively.
Focus: Immune system activation against cancer
Careers: Hiring in oncology, T-cell engineering, and immuno-oncology.
10. Manifold Bio
Using a unique barcoded protein system, Manifold Bio is advancing in vivo drug design to streamline therapeutic development from concept to validation.
Focus: In vivo drug design using protein barcoding
Careers: Protein engineering, AI drug discovery, data science.
11. Aviceda Therapeutics
Focused on glyco-immunology, Aviceda is developing clinical-stage treatments that modulate the innate immune system to tackle complex diseases.
Focus: Glyco-immune therapies
Careers: Biopharma project management, glycomics research, immuno-regulation.
12. Merida Biosciences
This startup is advancing precision medicine with a novel approach that targets and eliminates harmful antibodies implicated in autoimmune and inflammatory diseases.
Focus: Elimination of pathogenic antibodies
Careers: Autoimmune disorder research, lab operations, diagnostics.
13. Incendia Therapeutics
Incendia is working on antibody-based therapies designed to alter the tumor microenvironment, offering new hope for cancer treatment.
Focus: Monoclonal antibody therapies
Careers: Clinical development, tumor microenvironment specialists.
14. 1910 Genetics
Combining artificial intelligence and lab automation, 1910 Genetics is building a new framework for the discovery and development of both small and large molecule drugs.
Focus: AI + lab automation for drug discovery
Careers: ML engineers, lab automation scientists, computational biologists.
15. QLD Biotherapeutics Inc.
QLD is developing advanced cell and gene therapies, with a strong focus on innovation in genome editing and cell reprogramming techniques.
Focus: Advanced cell and gene therapies
Careers: CRISPR technicians, genetic therapy development, process optimization.
16. Kytopen
Kytopen develops tools that enable high-throughput cell engineering, opening new frontiers in functional antibody generation for treating immune conditions.
Focus: Precision cell engineering
Careers: Hiring in cell biology, microfluidics, and antibody production.
17. Spear Bio
Spear Bio’s proprietary SPEAR platform is redefining protein detection and quantification in diagnostic research, featuring an innovative two-factor validation process.
Focus: High-specificity diagnostics
Careers: Diagnostic assay developers, quality control engineers.
18. Vivtex
Vivtex has created the GI-ORIS™ platform, which uses robotic screening to evaluate drug absorption and delivery using intact gastrointestinal organ systems.
Focus: GI-ORIS™ robotic drug screening
Careers: Hiring robotics engineers, pharmaceutical scientists, and GI researchers.
19. Portal
A company enabling scalable and next-generation cell engineering for both research and clinical applications, Portal focuses on analytical solutions for cell biology.
Focus: Cell engineering and analytics
Careers: Hiring in cell therapy analytics, cloud biotech platforms.
20. Cugene Inc.
Cugene is developing precision therapeutics in immunology and oncology, using selective modulation of immune cell populations to treat diseases more effectively.
Focus: Precision immunology & oncology
Careers: Immunologists, precision medicine specialists, clinical study coordinators.
💼 Why These Startups Matter
Massachusetts remains a top biotech hub with VC funding, academic partnerships, and access to global pharma networks. Startups here offer high-paying, high-growth roles in translational medicine, computational biology, cell therapy, and clinical development. If you’re a scientist, engineer, or tech-savvy life sciences grad, now’s the time to tap into this ecosystem.
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